IκB kinase | TargetMol

カタログ番号	製品名	別名	ターゲット
TQ0306	MLN120B		IκB/IKK
	MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).		IκB/IKK
T6771	AZD3264		IκB/IKK
	AZD3264 is a new type IKK2 inhibitor.		IκB/IKK
T5540	GSK8612		IκB/IKK
	GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .		IκB/IKK
T15564	IMD-0560		IκB/IKK
	IMD-0560 is a novel inhibitor of IκB kinase β.		IκB/IKK
T1830	BX795		IκB/IKK , Chk , CDK , c-Kit , PDK , Autophagy
	BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than...		IκB/IKK , Chk , CDK , c-Kit , PDK , Autophagy
T5209	INH14		IκB/IKK
	INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).		IκB/IKK
T7951	TBK1/IKKε-IN-5		IκB/IKK
	TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).		IκB/IKK
T8705	BOT-64		IκB/IKK
	BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound		IκB/IKK
T10477	BAY-985		IκB/IKK
	BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with antitumor efficacy.		IκB/IKK
T15559	TBK1/IKKε-IN-2		IκB/IKK
	TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.		IκB/IKK
T10237	ACHP Hydrochloride	IKK-2 Inhibitor VIII	IκB/IKK
			IκB/IKK
T2081	LY2409881 trihydrochloride	LY2409881	Apoptosis , IκB/IKK
	LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM); IC50 for IKK1 and other common kinases is at least one log higher.		Apoptosis , IκB/IKK
T6141	IMD-0354	IKK2 Inhibitor V,IMD 0354	IκB/IKK
	IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.		IκB/IKK
T3094	PS-1145	IKK Inhibitor X	Apoptosis , IκB/IKK
	PS-1145 (IKK Inhibitor X) is a specific IKK inhibitor with IC50 of 88 nM.		Apoptosis , IκB/IKK
TD0099	Malachite green oxalate		Apoptosis , Others , IκB/IKK , NF-κB
	Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.		Apoptosis , Others , IκB/IKK , NF-κB
T6176	IKK 16	IKK Inhibitor VII,IKK-16,IKK16	IκB/IKK , LRRK2
	IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.		IκB/IKK , LRRK2
T2118	SC-514	GK 01140	IκB/IKK , p38 MAPK , Serine Protease , CDK , Aurora Kinase
	SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
T0097	MRT67307	MRT67307 HCl	IκB/IKK , Autophagy
	Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage...		IκB/IKK , Autophagy
T0708	Oxaprozin	Oxaprozinum,Wy21743	NF-κB , COX
	Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compound...		NF-κB , COX
T3049	TPCA-1	GW683965,IKK2 Inhibitor IV,TPCA1	Apoptosis , IκB/IKK , STAT
	TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzymes.		Apoptosis , IκB/IKK , STAT
T6326	BMS-345541	BMS-345541 free base,IKK Inhibitor III,BMS345541	IκB/IKK
	BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.		IκB/IKK
T1902	BAY 11-7082	BAY 11-7821	Apoptosis , Others , IκB/IKK , DUB , Autophagy
	BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM).		Apoptosis , Others , IκB/IKK , DUB , Autophagy
T1639	Amlexanox	CHX3673,Amoxanox,AA673	IL Receptor , FGFR , Others , IκB/IKK
	Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexan...		IL Receptor , FGFR , Others , IκB/IKK
T2279	Tizoxanide	Desacetyl-nitazoxanide,TIZ	Antiviral , HIV Protease , Antibacterial , Autophagy
	Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine. Lamivudine (2', 3'-dideoxy-3'-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).		Antiviral , HIV Protease , Antibacterial , Autophagy
T8542	BMS-345541 hydrochloride		IκB/IKK
	BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).		IκB/IKK
T25465	GS143	GS-143,GS 143	IκB/IKK , E1/E2/E3 Enzyme , NF-κB
	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea...		IκB/IKK , E1/E2/E3 Enzyme , NF-κB
T9105	NF-κB-IN-1	1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-	IκB/IKK , NF-κB
	NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 dir...		IκB/IKK , NF-κB
T2106	WS6		EGFR , IκB/IKK
	WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.		EGFR , IκB/IKK
T2055	WS3		EGFR , IκB/IKK
	WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.		EGFR , IκB/IKK
T23191	PS 1145 dihydrochloride		Others
	IκB kinase (IKK) inhibitor		Others
T41101	LY2409881	LY2409881
	LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.
T24470	Mitochonic Acid 35	MA35,MA-35,MA 35,Mitochonic Acid-35
	Mitochonic Acid 35 is a dual TNF-α and TGF-β1 inhibitor that acts by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation.
T15557	IKK 16 hydrochloride		Others
	IKK 16 hydrochloride is a selective IKK2, IKK complex, and IKK1 IκB kinase (IKK) inhibitor (IC50s: 40 nM, 70 nM and 200 nM, respectively). IKK16 inhibits leucine-rich repeat kinase-2 (LRRK2; IC50: 50 nM).		Others
T16464	Pelubiprofen		COX
	Pelubiprofen, an orally active non-steroidal anti-inflammatory drug (NSAID) belonging to the 2-arylpropionic acid family, selectively inhibits COX-2 activity alongside COX activity and the transforming growth factor-β ac...		COX
T63107	Anti-inflammatory agent 6
	Anti-inflammatory agent 6 exhibits anti-inflammatory potential by blocking the phosphorylation of Iκb kinase α/β (IKKα/β), IκBα and nuclear factor kB p65 (NF-κb p65), which are key controllers of inflammation.
T37449	SR 12460
	SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits T...
T83670	F1 TFA	Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide
	F1, an anti-inflammatory peptide, incorporates the HIV-1 Tat protein transduction domain linked with a 15-amino acid sequence from residues 46-60 of the inhibitor of NF-κB kinase-interacting peptide (IKIP). It effectivel...
T69898	NG25 trihydrochloride
	NG25 trihydrochloride is a type II kinase inhibitor that inhibits MAP4K2 and TAK1. It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK, FER, and p38α. NG 25 prevents TNF-α-induced I...
T36779	NG 25 (hydrochloride hydrate)
	NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinase...

Compounds

MLN120B

TQ0306

Target: IκB/IKK, Chk, CDK, c-Kit, PDK, Autophagy

Synonym: IKK-2 Inhibitor VIII

Target: IκB/IKK

LY2409881 trihydrochloride

T2081

Synonym: LY2409881

Target: Apoptosis, IκB/IKK

IMD-0354

T6141

Synonym: IKK2 Inhibitor V,IMD 0354

Target: IκB/IKK

PS-1145

T3094

Synonym: IKK Inhibitor X

Target: Apoptosis, IκB/IKK

Malachite green oxalate

TD0099

Synonym:

Target: Apoptosis, Others, IκB/IKK, NF-κB

IKK 16

T6176

Synonym: IKK Inhibitor VII,IKK-16,IKK16

Target: IκB/IKK, LRRK2

SC-514

T2118

Synonym: GK 01140

Target: IκB/IKK, p38 MAPK, Serine Protease, CDK, Aurora Kinase

MRT67307

T0097

Synonym: MRT67307 HCl

Target: IκB/IKK, Autophagy

Oxaprozin

T0708

Synonym: Oxaprozinum,Wy21743

Target: NF-κB, COX

TPCA-1

T3049

Synonym: GW683965,IKK2 Inhibitor IV,TPCA1

Target: Apoptosis, IκB/IKK, STAT

BMS-345541

T6326

Synonym: BMS-345541 free base,IKK Inhibitor III,BMS345541

Target: Apoptosis, Others, IκB/IKK, DUB, Autophagy

Amlexanox

T1639

Synonym: CHX3673,Amoxanox,AA673

Target: IL Receptor, FGFR, Others, IκB/IKK

Tizoxanide

T2279

Synonym: Desacetyl-nitazoxanide,TIZ

Target: Antiviral, HIV Protease, Antibacterial, Autophagy

BMS-345541 hydrochloride

Synonym: GS-143,GS 143

Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB

NF-κB-IN-1

T9105

Synonym: 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

Target: IκB/IKK, NF-κB

WS6

T2106

Synonym:

Target: EGFR, IκB/IKK

WS3

T2055

Synonym:

Target: EGFR, IκB/IKK

PS 1145 dihydrochloride

Synonym: MA35,MA-35,MA 35,Mitochonic Acid-35

Anti-inflammatory agent 6

Synonym: Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide

Target:

NG25 trihydrochloride

T69898

Synonym:

Target:

NG 25 (hydrochloride hydrate)

T36779

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T5796	Plantainoside D	Isoplantamajoside	RAAS , PKC
	Plantainoside D (Isoplantamajoside) shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM, it ...		RAAS , PKC
T1558	Resveratrol	trans-Resveratrol,SRT 501	Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
	Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
T0167	Vinpocetine	RGH-4405,Ethyl apovincaminate	IκB/IKK , NF-κB , Sodium Channel , PDE
	Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).		IκB/IKK , NF-κB , Sodium Channel , PDE
TN1504	Citreorosein		cAMP , NF-κB , PI3K
	Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation an...		cAMP , NF-κB , PI3K

カタログ番号	製品名	Species	Expression System
TMPY-02544	FANCA Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia (FA) is a genetic disorder predisposing to aplastic anemia and cancer characterized by h...

カタログ番号	製品名
L3800	NF-κB Signaling Compound Library		729 compounds
	A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;

検索結果

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

ライブラリー

Compounds

天然物製品

Recombinant Proteins

ライブラリー